Prevention of renal failure in rats receiving cis-diamminedichloroplatinum(II) by administration of furosemide.
نویسندگان
چکیده
The clinicopathological signs of renal failure induced in rats by weekly i.v. administration of cis-diamminedichloroplatinum(II) were prevented by pretreatment with furosemide. Weight loss, anemia, and generalized toxic effects of the drug were not effected by furosemide.
منابع مشابه
Prevention of Renal Failure in Rats Receiving cis Diamminedichloroplatinum(ll) by Administration of Furosemide
Chart 1. Funosemide protection against renal failure induced by DDP. F344 rats were given DDP, 3 mg/kg iv. weekly. Funosemide was given s.c. at a dose level of 12.5 mg/kg 30 mm before DDP. Groups of 5 rats were sacrificed from 0 to 6 weeks after initial drug administrations. All values are mean ±SE. The elevations of the renal weight and blood urea nitrogen values of rats given DDP are signifi...
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عنوان ژورنال:
- Cancer research
دوره 37 4 شماره
صفحات -
تاریخ انتشار 1977